tekst 1

Log in

Efficacy of Intravenous immunoglobulin and phototherapy in the management of extreme-hyperbilirubinaemia: A Case Report

Olufunke Bosede Bolaji, Sandeep Dhamaraj, Colin Lumsden, Olusegun Joseph Adebami

Disclosure: The author has declared no conflicts of interest.

DOI: 10.5455/IJMRCR.immunoglobulin-and-phototherapy-in-the-management-of-extreme-hyperbilirubinaemia

Fulltext PDF Download

Export to RefMan

Export to EndNote

Article Stats by PlumX


A case report of a term male neonate with extreme-hyperbilirubinaemia secondary to ABO incompatibility who was effectively managed with a combination of guided phototherapy and Intravenous immunoglobulin (IVIG) was presented. The patient responded well to treatment with no apparent immediate adverse effects. The challenges and lesson learnt is hereby presented.

Key words: Extreme-hyperbilirubinaemia, Intravenous immunoglobulin (IVIG), Guided phototherapy


1. Burke BL, Robbins JM, Bird TM, Hobbs CA, Nesmith C, Tilford JM. Trends in hospitalisations in neonatal jaundice and kernicterus in the United States, 1988-2005. Pediatrics 2009; 123:524-32
2. National Institute for Health and Clinical Excellence. Neonatal Jaundice. (Clinical Guideline 98); 2010. Available from http://www.nice.org.uk/CG98. Last accessed 8th August 2016
3. Alcock GS, Liley. Immunoglobulin infusion for isoimmunehaemolytic jaundice in neonates.Cochrane Database Syst Rev. 2002; 3: CD003313
4. BO Olusanya, FB Osibanjo, CA Mabogunje, TM Slusher, SA Olowe. The burden and management of neonatal jaundice in Nigeria: A scoping review of the literature. NJCP 2016;19:1-17.
5. Ibekwe RC, Ibekwe MU, Muoneke VU. Outcome of Exchange blood transfusions done for neonatal jaundice in Abakaliki, South Eastern Nigeria. Journal of Clinical Neonatology. 2012;1:34-37
6. Owa JA, Ogunlesi TA. Why are we still doing so many exchange blood transfusion for neonatal jaundice in Nigeria. World J Pediatr. 2009; 5:51-5
7. Nigerian consensus statement on newborn jaundice. Management of jaundice and prevention of extreme hyperbilirubinemia in infants ≥ 35 weeks gestation. Nigerian Expert Committee for severe hyperbilirubinemia (For NISONM)
8. Urbaniak SJ. ADCC (K Cell) lysis of human erythrocytes sensitized with Rhesus alloantibodies.II. Investigation into mechanism of lysis. Br J Haematol. 1979;42:315-328
9. Senterre T, Minon JM, Rigo J. Neonatal ABO incompatibility underlies a potentially severe hemolytic disease of the newborn and requires adequate care. Arch Pediatr. 2011;18:279-82
10. Ahlfors CE. Criteria for exchange transfusion in jaundiced newborns. Pediatrics 1994; 93:488-94
11. Greco C, Arnolda G, Boo NY, Iskander IF, Okolo AA, Rohsiswatmo R, et al. Neonatal jaundice in low- and middle- income countries: lessons and future directions from the 2015 Don Ostrow Trieste Yellow Retreat. Neonatology 2016;110:172-180
12. Cortey A, Elzaabi M, Waegemans T, Roch B, Aujard Y. [Efficacy and safety of intravenous immunoglobulins in the management of neonatal hyperbilirubinemia due to ABO incompatibility: a meta-analysis]. Arch Pediatr. 2014; 21:976- 83.
13. Miqdad AM, Abdelbasit, Shaheed MM, Seidahmed MZ, Abomelha AM, Arcala OP. Intravenous immunoglobulin G (IVIG) therapy for significant hyperbilirubinemia in ABO hemolytic disease of the newborn. J Matern Fetal Neonatal Med. 2004;16:163-6.
14. R Gottstein, RWI Cooke. Systematic review of intravenous immunoglobulin in hemolytic disease of the newborn. Arch Dis Chil Fetal Neonatal Ed 2003;88: F6-F10
15. Neonatal jaundice treatment and management. emedicine.medscape.com. accessed 8th August 2016.
16. BO Olusanya, Tinuade A Ogunlesi, Praveen Kumar, NemYun boo, Iman F Iskander, Maria Fernanda B de Almeida, et al. Management of late-preterm and term infants with hyperbilirubinaemia in resource-constrained settings. BMC Paediatrics 2015;15:39

How to Cite This Article

Bolaji O, Dhamaraj S, Lumsden C, Adebami O. Efficacy of Intravenous immunoglobulin and phototherapy in the management of extreme-hyperbilirubinaemia: A Case Report. International Journal of  Medical Reviews and Case Reports [Internet]. ScopeMed International Medical Journal Management and Indexing System; 2017;1(2):1.

Last modified onWednesday, 29 August 2018 10:44

Leave a comment

Make sure you enter the (*) required information where indicated. HTML code is not allowed.