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Kikuchi-Fujimoto disease: case report and review

Featured Kikuchi-Fujimoto disease: case report and review

Irami Araujo-Filho, Artur Dantas Freire, Irami Araújo-Neto, Carolina Chianca Dourado Lemos, Letícia Araújo Costa Uchôa, Amália Cínthia Meneses Rêgo, Marco Antônio Botelho Soares, José Francisco Correia-Neto, Carlos André Nunes Jatobá, Ana Maria de Oliveira Ramos

Disclosure: The author has declared no conflicts of interest.

DOI: 10.5455/IJMRCR.kikuchi-fujimoto-disease

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OBJECTIVE: The development of associated febrile to lymphadenomegaly leads to several diagnostic hypotheses, among them the Kikushi-Fujimoto disease.
METHOD: This review was set up by searching PubMed/Medline, Web of Science and Scopus database using the following key words: “Kikushi disease”, “Kikuchi-Fujimoto disease”, “histiocytic necrotizing”, “lymphadenitis”, “lymphadenopathy”.
RESULTS: We report a case in a young patient with a fever associated with the emergence of adenomegalies and weight loss in two months, associated with hepatosplenomegaly. In laboratory tests showed anemia with erythrocyte sedimentation rate (ESH) and lactate dehydrogenase (LDH) test elevated, widened mediastinum, with bilateral pleural effusion.
CONCLUSION: Excisional biopsy of supraclavicular lymph node showed Kikuchi-Fujimoto disease on microscopic examination. After histopathological confirmation, were other causes of febrile adenomegalias apart, starting dose corticosteroid immunosuppressive therapy.

Key words: Kikushi disease; Kikuchi-Fujimoto disease; histiocytic necrotizing lymphadenitis; lymphadenopathy.


1.Yen A, Fearneyhough P, Raimer SS, Hudnall SD. EBV-
associated Kikuchi’s histiocytic necrotizing lymphadenitis
with cutaneous manifestations. J Am Acad Dermatol 1997;
2.Hudnall SD, Chen T, Amr S, et al. Detection of human
herpesvirus DNA in Kikuchi-Fujimoto disease and reactive
lymphoid hyperplasia. Int J Clin Exp Pathol 2008; 1:362.
3.Huh J, Kang GH, Gong G, et al.
Kaposi’s sarcoma-
associated herpesvirus in Kikuchi’s disease. Hum Pathol
1998; 29:1091.
4.Yufu Y, Matsumoto M, Miyamura T, et al. Parvovirus
B19-associated haemophagocytic syndrome with lym-
phadenopathy resembling histiocytic necrotizing lym-
phadenitis (Kikuchi’s disease). Br J Haematol 1997; 96:868.
5.Iguchi H, Sunami K, Yamane H, et al. Apoptotic cell death
in Kikuchi’s disease: a TEM study. Acta Otolaryngol Suppl
1998; 538:250.
6.Ohshima K, Shimazaki K, Kume T, et al. Perforin and Fas
pathways of cytotoxic T-cells in histiocytic necrotizing lym-
phadenitis. Histopathology 1998; 33:471.
7.Ura H, Yamada N, Torii H, et al. Histiocytic necrotizing
lymphadenitis (Kikuchi’s disease): the necrotic appearance
of the lymph node cells is caused by apoptosis. J Dermatol
1999; 26:385.
8.Dorfman RF, Berry GJ. Kikuchi’s histiocytic necrotizing lym-
phadenitis: an analysis of 108 cases with emphasis on dif-
ferential diagnosis. Semin Diagn Pathol 1988; 5:329.
9.Asano S, Akaike Y, Jinnouchi H, et al. Necrotizing lym-
phadenitis: a review of clinicopathological, immunohisto-
chemical and ultrastructural studies. Hematol Oncol 1990;
10.Lin HC, Su CY, Huang CC, et al. Kikuchi’s disease: a review
and analysis of 61 cases. Otolaryngol Head Neck Surg 2003;
11.Tsang WY, Chan JK, Ng CS. Kikuchi’s lymphadenitis. A
morphologic analysis of 75 cases with particular reference
to unusual features. Am J Surg Pathol 1994; 18:219.
12.Lee KY, Yeon YH, Lee BC. Kikuchi-Fujimoto disease with
prolonged fever in children. Pediatrics 2004; 114:e752.
13.Payne JH, Evans M, Gerrard MP. Kikuchi-Fujimoto disease:
a rare but important cause of lymphadenopathy. Acta Pae-
diatr 2003; 92:261.
14.Ray A, Muse VV, Boyer DF. Case records of the Mas-
sachusetts General Hospital. Case 38-2013. A 30-year-old
man with fever and lymphadenopathy. N Engl J Med 2013;
15.Infante MJ, Lovillo C, Santaella IO, Checa RM, González
MR. Enfermedad de Kikuchi-Fujimoto como causa de lin-
fadenopatías. An Pediatr (Barc). 2007;67(1):83-5.
16.Kucukardali Y, Solmazgul E, Kunter E, et al. Kikuchi-
Fujimoto Disease: analysis of 244 cases. Clin Rheumatol
2007; 26:50.
17.Kuo TT. Cutaneous manifestation of Kikuchi’s histiocytic
necrotizing lymphadenitis. Am J Surg Pathol 1990; 14:872.
18.Kuo TT. Kikuchi’s disease (histiocytic necrotizing lym-
phadenitis). A clinicopathologic study of 79 cases with
an analysis of histologic subtypes, immunohistology, and
DNA ploidy. Am J Surg Pathol 1995; 19:798.
19.Norris AH, Krasinskas AM, Salhany KE, Gluckman SJ.
Kikuchi-Fujimoto disease: a benign cause of fever and lym-
phadenopathy. Am J Med 1996; 101:401.
20.Bailey EM, Klein NC, Cunha BA. Kikuchi’s disease with
liver dysfunction presenting as fever of unknown origin.
Lancet 1989; 2:986.
21.Song JY, Cheong HJ, Kee SY, et al. Disease spectrum of cer-
vical lymphadenitis: analysis based on ultrasound-guided
core-needle gun biopsy. J Infect 2007; 55:310.
22.Smith KG, Becker GJ, Busmanis I. Recurrent Kikuchi’s dis-
ease. Lancet 1992; 340:124.
23.Patra A, Bhattacharya SK. SLE Developing in a Follow-Up
Patient of Kikuchi’s Disease: A Rare Disorder. J Clin Diagn
Res 2013; 7:752.
24.Mital D, Desai V, Chin K. Kikuchi-Fujimoto syndrome pre-
senting to a sexual health clinic. Int J STD AIDS 2009; 20:140.
25.Dorfman RF, Warnke R. Lymphadenopathy simulating the
malignant lymphomas. Hum Pathol 1974; 5:519.
26. Nieman RB. Diagnosis of Kikuchi’s disease. Lancet 1990;
27.Tsang WY, Chan JK. Fine-needle aspiration cytologic diag-
nosis of Kikuchi’s lymphadenitis. A report of 27 cases. Am
J Clin Pathol 1994; 102:454.
28.Mannarà GM, Boccato P, Rinaldo A, et al. Histiocytic necro-
tizing lymphadenitis (Kikuchi-Fujimoto disease) diagnosed
by fine needle aspiration biopsy. ORL J Otorhinolaryngol
Relat Spec 1999; 61:367.
29. Atwater AR, Longley BJ, Aughenbaugh WD. Kikuchi’s dis-
ease: case report and systematic review of cutaneous and
histopathologic presentations. J Am Acad Dermatol 2008;
30.Ohshima K, Karube K, Hamasaki M, et al. Apoptosis- and
cell cycle-associated gene expression profiling of histiocytic
necrotising lymphadenitis. Eur J Haematol 2004; 72:322.
31.Kishimoto K, Tate G, Kitamura T, et al. Cytologic features
and frequency of plasmacytoid dendritic cells in the lymph
nodes of patients with histiocytic necrotizing lymphadenitis
(Kikuchi-Fujimoto disease). Diagn Cytopathol 2010; 38:521.
32.Kwon SY, Kim TK, Kim YS, et al. CT findings in Kikuchi
disease: analysis of 96 cases. AJNR Am J Neuroradiol 2004;
33.Youk JH, Kim EK, Ko KH, Kim MJ. Sonographic features
of axillary lymphadenopathy caused by Kikuchi disease. J
Ultrasound Med 2008; 27:847.
34.Jang YJ, Park KH, Seok HJ. Management of Kikuchi’s dis-
ease using glucocorticoid. J Laryngol Otol 2000; 114:709.
35.Lin DY, Villegas MS, Tan PL, et al. Severe Kikuchi’s disease
responsive to immune modulation. Singapore Med J 2010;
36. Rezai K, Kuchipudi S, Chundi V, et al. Kikuchi-Fujimoto
disease: hydroxychloroquine as a treatment. Clin Infect Dis
2004; 39:e124

How to Cite This Article

ARAJOFILHO I, Freire A, ArajoNeto I, Lemos C, Ucha L, Rgo A, et al. Kikuchi-Fujimoto disease: case report and review. International Journal of  Medical Reviews and Case Reports [Internet]. ScopeMed International Medical Journal Management and Indexing System; 2017;1.

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