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Efficacy of Intravenous immunoglobulin and phototherapy in the management of extreme-hyperbilirubinaemia: A Case Report

Olufunke Bosede Bolaji, Sandeep Dhamaraj, Colin Lumsden, Olusegun Joseph Adebami

DOI: 10.5455/IJMRCR.immunoglobulin-and-phototherapy-in-the-management-of-extreme-hyperbilirubinaemia

Int J Med Rev Case Rep. 2017; 1(2): 28-31

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What we can learn from this publication?

Administration of intravenous immunoglobulin (IVIG) to newborns with significant hyperbilirubinemia due to ABO haemolytic disease with positive direct Coomb’s test combined with the use of phototherapy (PT) reduces the need for exchange blood transfusion (EBT) and the duration of PT. The efficacy and good tolerance prompt consideration of IVIG as a therapeutic adjuvant to PT in severe hemolytic hyperbilirubinemia due to ABO incompatibility. Since it appears safe, it may also have a role in special circumstances such as parental refusal for exchange transfusion, failed cannulation for EBT or where appropriate blood components for exchange transfusion are unavailable. This case report also encourages the employment of standard protocols which are widely available in determining the need for phototherapy or exchange blood transfusion as well as the use of alternative treatments like IVIG in cases of extreme hyperbilirubinaemia with isoimmunization. This maximises the chances of a favourable outcome for patients with severe neonatal jaundice regarding reducing the need for EBT and the duration of accompanying phototherapy.


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How to Cite This Article

Bolaji O, Dhamaraj S, Lumsden C, Adebami O. Efficacy of Intravenous immunoglobulin and phototherapy in the management of extreme-hyperbilirubinaemia: A Case Report. International Journal of  Medical Reviews and Case Reports [Internet]. ScopeMed International Medical Journal Management and Indexing System; 2017;1(2):1.

Last modified onSaturday, 09 November 2019 00:27